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Before investing, please consider the fund’s investment objectives, risks, charges, and expenses. You may obtain a prospectus or a summary prospectus here containing this and other information. Read it carefully.

The Clough Capital Partners L.P. ("Clough Capital") ETFs are distributed by Vigilant Distributors, LLC.

Investing involves risk. Principal loss is possible. The Clough Long/Short Equity ETF and the Clough Select Equity ETF (the "Clough ETFs" or the "Funds"). The equity securities held in the portfolio may experience sudden, unpredictable drops in value or long periods of decline in value. This may occur because of factors that affect securities markets generally or factors affecting specific issuers, industries, or sectors in which the Funds invest.

Short selling involves the sale of securities borrowed from a third party. The short seller profits if the borrowed security’s price declines. If a shorted security increases in value, a higher price must be paid to buy the stock back to cover the short sale, resulting in a loss. The Clough Capital ETFs may incur expenses related to short selling, including compensation, interest or dividends, and transaction costs payable to the security lender, whether the price of the shorted security increases or decreases. The amount the Clough Capital ETF's could lose on a short sale is theoretically unlimited. Short selling also involves counterparty risk – the risk associated with the third party ceasing operations or failing to sell the security back.

Applying ESG criteria to the investment process may exclude securities of certain issuers for non-investment reasons and therefore the Funds may forgo some market opportunities available to funds that do not use ESG criteria. The Funds' incorporation of ESG considerations may affect its exposure to certain sectors and/or types of investments, and may adversely impact the Funds' performance depending on whether such sectors or investments are in or out of favor in the market.

To receive quarterly reports, market commentary, and updates related to Clough Capital, contact us via phone or email.

Clough Capital Partners L.P.

53 State Street
27th Floor
Boston MA 02109

(617) 204-3400

investorrelations@cloughcapital.com

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